Betting nugget: Last season, first-round quarterbacks making their first career starts went 0-5 ATS. NFL picks, predictions for Week 5: Cardinals crush 49ers; Steelers stop He is tied with Russell Wilson for the most in the NFL in that span. But Browns RB Nick Chubb leads the NFL in rushing first downs and rushes of 10-plus yards. Lions 28, Panthers 20 -- Michael Rothstein, This is the second of three consecutive road games for the Niners, and they're coming off a trio of games they lost by a combined eight points. Read more. -- Marcel Louis-Jacques. See Week 5 rankings. Victor Cruz contends that Gardner Minshew is better equipped to lead his team to victory in the matchup with Panthers QB Kyle Allen. To take advantage of the Ravens' weak spot, the Steelers could push Rudolph to unleash more deep throws. ET | Fox Panthers 24, Lions 21 -- David Newton, Defending Newton will be tough, and linebacker Luke Kuechly could cause Stafford some issues, but the Lions have shown they are one of the better teams in the NFC. Matchup rating: 49.4 | Spread: LAC -6.5 (44.5), What to watch for: With Denver desperate for a win and fellow edge rusher Bradley Chubb done for the year because of an ACL injury, look for Von Miller to ignite the Broncos by getting after Philip Rivers, who has limited mobility. Matchup rating: 9.9 | Spread: CIN -3 (46.5), What to watch for: The game between winless teams could feature multiple sacks. Washington's pass defense is allowing 259.8 yards per game, but 294 yards per game at home. DET-NE | CHI-MIN | MIA-NYJ But the Chargers are the right opponent at the right time. XFL odds, picks, predictions for XFL playoffs: Sea Dragons, Roughnecks The story of the Cowboys scout and prospect son Dallas just drafted, Legacy pick: Cardinals take great-great-nephew of team's first-ever draft pick, Winston already improving under 'QB whisperer' Bruce Arians, Yes, he's 2-0, but the Saints will need more from Bridgewater, Matthew Berry's Love/Hate for Week 5: How to make a trade, NFL experts predict: Week 5 upset picks, fantasy football flops and sleepers, How Watson's 'NFL experience' began as ball boy for the Falcons, TE Hooper could be the next Falcon to cash in, Taylor Lewan's return could be a boon for Titans' offense, Gore closing on No. See Week 5 rankings. Eli Manning beats Philip Rivers for the first time in his career. What to know for fantasy: With two games of seven-plus targets already this season, plus a TD reception in Week 4, Bengals tight end Hayden Hurst has potential. Matchup rating: 56.9 | Spread: SF -3.5 (46.5), What to watch for: The 49ers are missing left tackle Joe Staley and cornerback Ahkello Witherspoon, both of whom play positions opposite Cleveland's best players in defensive end Myles Garrett (and DE/LB Olivier Vernon, depending on alignment) and receiver Odell Beckham Jr. With backups in the lineup, can the Niners neutralize two of Cleveland's biggest stars? NFL Week 5 Early Odds, Picks & Predictions (2022) | BettingPros This should be a prime spot for them to get on track, even with the uncertainty surrounding receiver Stefon Diggs. Gregg Rosenthal went 10-6 . NFL: Notable Super Bowl betting trends It all culminates with a Monday Night Football matchup between the Raiders and the Chiefs on ESPN. The Saints quarterback is remarkably 2-0 as Drew Brees' replacement, but he has thrown for an average of only 185 yards per game in those two starts. What to know for fantasy: Baker Mayfield averaged one touchdown pass every 18 attempts as a rookie. Ertz has not scored this season, but his 24 catches rank fourth at the position this season and keep his floor high. In most cases, he'd be right, but there has been a sense of satisfaction this week in the Jets' locker room -- a possible red flag. With the return of Michael Gallup, Lamb will have chances to get away from Jalen Ramsey to make more plays. 1 in both defensive efficiency and QBR allowed in that span. Wagoner's pick: 49ers 27, Browns 24 Game of Midweek: Colts at Broncos (-3.5, 44 o/u) . Paired with fellow receivers John Brown and Jaron Brown, the Arizona wideouts pose a threat to a vulnerable Eagles cornerback group. At 0-4, the Browns talked a good game all week, but there was a feeling that folks were looking over their shoulder. This season, Cooks has zero 100-yard receiving games and has averaged just 53 yards per game. What to know for fantasy: DK Metcalf had the big Week 4, but Tyler Lockett has benefited most from the overachieving of Smith more than 75 receiving yards in three straight games. Time/station: 8:20 PM EST, ESPN. What to watch for: The Patriots have given up 325 rushing yards on 51 carries (6.37 on average) over their past six quarters . ET | Fox NFL Nation reporters predict the outcomes and scores for Sunday's and Monday's Week 5 games. Rams 23, Seahawks 20 -- Alden Gonzalez, The Ravens catch a break with EJ Manuel starting at quarterback for the injured Derek Carr. Even at full strength, Seattle's offensive line will have its hands full against a Rams front four that has given the Seahawks all sorts of trouble during the past few seasons. Bengals 13, Bills 9 -- Mike Rodak, The Bengals have a tough matchup against one of the league's best defenses (Buffalo is 10th overall), but it looks like their offense finally has begun to click in the past two weeks. All newly updated picks . Why Lions GM is getting high praise Our experts share their favorite upset picks for Week 5, including an unsuspecting team who is 3-1 to start the year. Betting nugget: The past four times Jacksonville was a favorite, it lost the game outright, with three of those losses coming against Houston. ET | Fox (1:06). These two teams just played each other in the regular season finale last week when the Roughnecks won 25-9 despite Brandon Silvers, Max Borghi, Deontay Burnett, and Brycen Alleyne all sitting. Davenport's pick: Titans 17, Bills 14 FPI prediction: ARI, 56.4% (by an average of 1.8 points), Matchup must-reads: Miles Sanders' emergence makes the Eagles so much better Defense keeps Cardinals afloat while offense figures it out, What to watch for: Matthew Stafford has been sacked 16 times this season, which is tied for the second most in the NFL. Pickett was picked off three times while playing in the second half last week vs. the Jets, and his ability to make good decisions on the road will go a long way against a defense tied for the league lead in interceptions (seven). Projecting the Giant's first-round pick, Moody's pick: Saints 27, Seahawks 24 ESPN Reporter Claims Aaron Rodgers Deal Affected NFL Schedule Release Moody's pick: Packers 31, Giants 14 -- Mike DiRocco, Bold prediction: Texans wideout Brandin Cooks will have his best outing of the season with a 100-yard game. . Los Angeles Chargers at New Orleans Saints. 3 all-time rusher Barry Sanders, Meet Brady's most trusted teammate: His 1995 shoulder pads, Redskins' January decision to maintain status quo looks bad in hindsight, Patriots' offense searching for identity, as it did in 2018, Big pass plays tearing up Ravens' defense, 'Do whatever' to win: Steelers bring back the Wildcat, Raiders hoping to reverse London trend by changing travel schedule, Left with no defense, Jackson needs to carry Ravens this season, Steelers' first draft by Khan 'aggressive', Mack expected to be with the Raiders 'for the long haul', Daniel embraces seldom-used, uncertain backup QB life, Carr: Burfict's 'heart is broken;' QB says ban isn't fair, Analyzing how, where Golden Tate fits into Giants' offense. Tyrod Taylor has excelled in passing to Charles Clay and LeSean McCoy this season, but the Bengals boast the NFL's lowest yards per catch (6.49) by opposing tight ends and running backs. Read more. No 49ers player has done that in three straight games since Billy Kilmer in 1961. Stat to know: Jacksonville receiver DJ Chark Jr. has 19 receptions for 321 yards and three scores this season. Betting nugget: Bridgewater is 25-7 against the spread (ATS) in his career as a starting quarterback, the best mark by any QB with at least 15 starts in the Super Bowl era. The Raiders opened the season with three of their first four games on the road. -- Rob Demovsky, Bold prediction: Aaron Rodgers throws for 300-plus yards and at least three touchdowns. More: NFL Week 5 odds: Money lines, point spreads, over/under for every Week 5 NFL game. Stat to know: JuJu Smith-Schuster's 15 receiving yards against the Bengals were the fewest he has had in a regular-season game in which he registered at least one reception. See Week 5 rankings. The offense remains a question mark, however, and could be without starting left tackle Rees Odhiambo because of a chest injury. NFL picks, predictions for Week 5 Los Angeles Rams (-1.5) at Seattle Seahawks Thursday, 8:20 p.m., FOX/NFL Network The NFC West grinder continues. And the Dolphins' struggling offense presents three receivers who could give them fits once again. Matchup rating: 52.4 | Spread: NE -15 (42), What to watch for: Can the Redskins do anything to slow the Patriots' offense? Transactions | Injuries Matchup rating: 77.2 | Spread: DAL -3.5 (46.5), What to watch for: Can the Packers' defense replicate what New Orleans did a week ago in holding Ezekiel Elliott to 35 yards on 18 carries? Betting nugget: Atlanta is 4-0 ATS this season, all as an underdog. DiRocco's pick: Panthers 17, Jaguars 16 Josh McCown has completed 75 percent of his passes against the blitz, which bodes well against the blitz-heavy Browns, who have allowed a 127 passer rating when blitzing. For context, 5.2 yards per rush with McCoy on the field would rank fifth in the NFL among all teams this season, as opposed to 27th when McCoy isn't on the field. -- Sarah Barshop, Bold prediction: The Falcons, who have been outscored 38-10 in first quarters this season, will actually have the lead after the first frame in Houston. -- Katherine Terrell, Bold prediction: Ryan Neal will take over for Josh Jones in the starting lineup and spark Seattle's struggling defense with a game-changing takeaway. No one really knows what to expect. Gutierrez's pick: Bears 20, Raiders 16 But can the Colts keep possession effectively enough to pull the upset? The Cards are dead last in the league with four sacks entering Week 5. -- Ben Baby, NFL: Brady a rare Super Bowl underdog Without Tyreek Hill, Chiefs' receiving load shifting to tight ends and backs Patrick Mahomes says Andy Reid 'stole the show' in TV ad, 9:30 a.m. Read more. 2023 NFL draft buzz: McShay on top prospects, QBs, early picks - ESPN Full schedule | Standings "His quickness with power is awesome," said Rivers about Miller, who has 16 career sacks against the Chargers. Legwold's pick: Chargers 23, Broncos 21 Rodgers hasn't topped 255 yards passing this season, and the Giants have the eighth-ranked pass defense. Moody's pick: 49ers 27, Panthers 10 ET | CBS The Bills might be 3-1 and playing the 1-3 Bengals, but Vegas seems to like Cincinnati in this game. -- Todd Archer. Betting nugget: Chicago is 4-12 ATS as an underdog since the start of last season. See Week 5 rankings. Read more. FREE to play! -- Tim McManus. NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round . 1, Panthers' Bryce Young is all 'business now', Top picks Christian Gonzalez, Keion White reflect Patriots' ideal identity, Big takeaways from the NFL draft: A historic QB class, the rebuilt AFC South and new GMs thriving, NFL Nation sizes up all 259 draft selections, XFL semifinals: Defenders roll Sea Dragons, set up title showdown with Renegades. But Minnesotas defense is tough. Stat to know: The Dolphins' 11-2 record since 2021 Week 9 is tied with the Chiefs for best in the NFL. Here's how Week 5 is shaping up as we continue through the 2021 season CBSSports.com . The Bucs also gave up an uncharacteristic 189 rushing yards in their 41-31 loss to the Kansas City Chiefs last week -- the most they've surrendered since 2018. As Giants defensive coordinator Wink Martindale said of the Packers QB, 'It's like owning a python and saying, 'Don't worry about it, he won't bite.'" More NFL coverage , Bold prediction: The Bucs will hold Alvin Kamara under 100 all-purpose yards and under 45 rushing yards. What to know for fantasy: Zach Ertz finished last season as TE2 despite not scoring his first touchdown until Week 5. (Game times are Sunday unless otherwise noted. NFL Week 5 schedule and game-by-game predictions See Week 5 rankings. This is the second-longest current home losing streak in the NFL behind the Cardinals, who have dropped seven in a row at home. -- Brady Henderson. -- Tim McManus. Read more. Lions (1-3) at Patriots (1-3) 1 p.m. We answered the biggest post-draft question for all 32, LB Barrett's 2-year-old daughter drowns in pool, Deion 'ashamed' after only 1 HBCU player drafted, Sources: NFL eyes May 11 to release schedule, Teams set NFL record with 43 trades during draft, Jets coach Saleh: Rodgers making 'presence felt', Cowboys scout emotional as team drafts his son, Rams use 'Mr.

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